张丽（邮箱：lilyz@njucm.edu.cn），副教授，南京大学博士，硕士生导师，南京中医药大学C类特聘教授引进人才。主要从事外泌体小RNA药物的开发及其在神经精神疾病中的作用研究。主持国家自然科学基金项目、江苏省自然科学基金项目、南京中医药大学特聘教授科研经费项目。在 Brain、Journal of Controlled Release等国际知名期刊发表SCI论文多篇，其中博士期间发表于Brain的相关成果进入转化，所研发的小核酸药物获美国FDA孤儿药资格认定及中美两国临床试验许可，目前临床Ⅰ期试验正在进行中。

代表性论文：

1. Zhang L#, Wu TT#, Shan YY#, Li G#, Ni X, Chen XR, Hu XT, Lin LS, Li YC, Guan YL, Gao JF, Chen DB, Zhang Y, Pei Z, Chen X. Therapeutic reversal of Huntington's disease by in vivo self-assembled siRNAs. Brain, 2021, 144(11): 3421-3435.

2. Zhang L#, Chen PL#, Chen TT, Lin LS, Ji XY, Liu J, Huang H, Saravanan T, Fuehrer H, Ross CA, Smith WW, Pei Z, Chen X. In vivo self-assembled siRNAs within small extracellular vesicles attenuate LRRK2-induced neurodegeneration in Parkinson's disease models. J Control Release, 2025, 378: 1139-1153.

3. Wang H#, Zhang L#, Yang WY, Ji X, Gao AQ, Wei YH, Ding X, Kang Y, Ding JH, Fan Y, Lu M, Hu G. Visceral adipose tissue-derived extracellular vesicles promote stress susceptibility in obese mice via miR-140-5p. Acta Pharmacol Sin, 2025.

4. Wang QQ#, Zhang L#, Weng H, Wang Q, Chen PL, Chen H, Jiang RR, Xu GH, Bai YM, Chen X. A pilot study on the mechanism of Guasha in treating Parkinson's disease based on molecular level and ultra-trace proteomics analysis. Chinese J Anal Chem, 2024, 52(6).

5. Li ZZ#, Du XH#, Yang YX, Zhang L, Chen PL, Kan YS, Pan JM, Lin LS, Liu D, Jiang XH, Zhang CY, Pei Z, Chen X. Treatment of neurologic pathology and inflammation in Machado-Joseph disease through in vivo self-assembled siRNA. Brain, 2024, 148(3): 817-832.