杨开勇（邮箱：yangky003@njucm.edu.cn）, 博士，副教授，硕士研究生导师。现任职于南京中医药大学医学院，入选江苏省“双创博士”、江苏省“青年人才托举工程”。担任教育部学位中心评审专家、中国药理学会会员、中国化学会会员、中国生物医学工程学会会员。
主要从事肺癌免疫耐受微环境的动态演化与重编程策略研究，相关研究成果发表SCI学术论文20余篇，其中包括Science Advances、Angewandte Chemie International Edition、British journal of pharmacology等国际知名期刊。主持国家和部省级等课题5项。目前担任Medicine Bulletin杂志青年编委以及Journal of Advanced Research、npj Precision Oncology、Journal of Nanobiotechnology、Cancer Nanotechnology等学术杂志审稿专家。
代表性论文
1. Yang Kaiyong#, Li Zijian#, Chen Yan, Yin Fangzhou, Ji Xiaojun, Zhou Jiaqian, Li Xin, Zeng Tao, Fei Chenghao, Ren Chenchen, Wang Yulin, Fang Lei, Chen Lili, Zhang Pei, Mu Liyan, Qian Yuxuan, Chen Yan*, Yin Wu*. Na, K-ATPase α1 cooperates with its endogenous ligand to reprogram immune microenvironment of lung carcinoma and promotes immune escape. Science Advances. 2023;9(6):eade5393.
2. Yang Jingjing#, Yang Kaiyong#, Du Shiyu, Luo Wen, Wang Chao, Liu Hongmei, Liu Kunguo, Zhang Zhibin, Gao Yanfeng, Han Xin*, Song Yujun*. Bioorthogonal Reaction-Mediated Tumor-Selective Delivery of CRISPR/Cas9 System for Dual-Targeted Cancer Immunotherapy. Angewandte Chemie International Edition. 2023;62(37):e202306863.
3. Yang Kaiyong#, Zhang Chunli#, Wang Zeyu#, Huang Qiqing, Qian Jing, Shi Gaoyu, Sun Wenwen, Wang Jinqiu, Ji Yu, Sun Zhaorui*, Song Yanni*, Han Xin*. CRISPR-dCas9-Mediated PTEN Activation via Tumor Cell Membrane-Coated Nanoplatform Enhances Sensitivity to Tyrosine Kinase Inhibitors in Nonsmall Cell Lung Cancer. ACS Applied Materials & Interfaces. 2025;17(9):13605-16.
4. Yan Tao#, Yang Kaiyong#, Chen Chao, Zhou Zhiruo, Shen Peiliang, Jia Yuanyuan, Xue Yu, Zhang Zhenyu, Shen Xu*, Han Xin*. Synergistic photothermal cancer immunotherapy by Cas9 ribonucleoprotein-based copper sulfide nanotherapeutic platform targeting PTPN2. Biomaterials. 2021;279:121233.
5. Zhou Y#, Sun W#, Zhou J, Yang P, Wang J, Xu B*, Hou J*, Yang Kaiyong*. Bu Zhong Yi Qi Tang targets key monocyte-associated genes to enhance sepsis therapy. Journal of Ethnopharmacology. 2026 Jan 30;355(Pt A):120610.
