杨开勇（邮箱：yangky003@njucm.edu.cn），博士，副教授，硕士研究生导师。江苏省“双创博士”，中国药理学会会员、中国化学会会员、中国生物医学工程学会会员。
主要从事代谢调控与中药协同增强抗肿瘤免疫应答机制及临床转化研究。相关研究成果发表SCI学术论文10余篇，其中包括Science Advances、Angewandte Chemie International Edition、British journal of pharmacology等国际主流期刊。主持国家自然科学基金青年项目、江苏省高校自然科学基金面上项目。目前担任Journal of Advanced Research、Cancer Nanotechnology学术杂志审稿专家。
代表性研究论文
1.Yang Kaiyong#, Li Zijian#, Chen Yan, Yin Fangzhou, Ji Xiaojun, Zhou Jiaqian, Li Xin, Zeng Tao, Fei Chenghao, Ren Chenchen, Wang Yulin, Fang Lei, Chen Lili, Zhang Pei, Mu Liyan, Qian Yuxuan, Chen Yan*, Yin Wu*. Na, K-ATPase α1 cooperates with its endogenous ligand to reprogram immune microenvironment of lung carcinoma and promotes immune escape. Science Advances. 2023;9(6):eade5393.
2.Yang Jingjing#, Yang Kaiyong#, Du Shiyu, Luo Wen, Wang Chao, Liu Hongmei, Liu Kunguo, Zhang Zhibin, Gao Yanfeng, Han Xin*, Song Yujun*. Bioorthogonal Reaction-Mediated Tumor-Selective Delivery of CRISPR/Cas9 System for Dual-Targeted Cancer Immunotherapy. Angewandte Chemie International Edition. 2023;62(37):e202306863.
3.Yang Kaiyong#, Zhang Chunli#, Wang Zeyu#, Huang Qiqing, Qian Jing, Shi Gaoyu, Sun Wenwen, Wang Jinqiu, Ji Yu, Sun Zhaorui*, Song Yanni*, Han Xin*. CRISPR-dCas9-Mediated PTEN Activation via Tumor Cell Membrane-Coated Nanoplatform Enhances Sensitivity to Tyrosine Kinase Inhibitors in Nonsmall Cell Lung Cancer. ACS Applied Materials & Interfaces. 2025;17(9):13605-16.
4.Yan Tao#, Yang Kaiyong#, Chen Chao, Zhou Zhiruo, Shen Peiliang, Jia Yuanyuan, Xue Yu, Zhang Zhenyu, Shen Xu*, Han Xin*. Synergistic photothermal cancer immunotherapy by Cas9 ribonucleoprotein-based copper sulfide nanotherapeutic platform targeting PTPN2. Biomaterials. 2021;279:121233.
5.Yang Kaiyong, Chen Yan, Zhou Jiaqian, Ma Lin, Shan Yating, Cheng Xiaoying, Wang Yun, Zhang Zhaoxin, Ji Xiaojun, Chen Lili, Dai Hui, Zhu Biqing, Li Chen, Tao Zhonghua, Hu Xichun*, Yin Wu*. Ursolic acid promotes apoptosis and mediates transcriptional suppression of CT45A2 gene expression in non-small-cell lung carcinoma harbouring EGFR T790M mutations. British journal of pharmacology. 2019;176(24):4609-24.
