曹楠(邮箱:ncao@njucm.edu.cn),博士,教授,博士研究生导师,就职于医学院病原生物学与免疫学系。江苏省特聘教授。
主要从事一类拓扑异构酶,结核分枝杆菌拓扑异构酶与DNA的相互作用机制,以及以细菌拓扑异构酶为靶点的抗菌药物的研究。相关研究成果发表SCI学术论文4篇 。
代表性研究论文
1.Ioannou, D., Jiang, Z., Cao, N., Ren, Y., Becerra, V., Vaccarella, A., Kandukuri, L., and Tempest, G.H. (2014) Gene repositioning in human lymphocytes following exposure to genotoxic agents. Conference paper in Chromosome Research
2.Tan, K., Cao, N., Cheng, B., Joachimiak, A., and Tse-Dinh, Y. C. (2016). Insights from the Structure of Mycobacterium tuberculosis Topoisomerase I with a Novel Protein.Fold. J Mol Biol, 428(1), 182- 193.
3.Banda, S., Cao, N., and Tse-Dinh, Y. C. (2017). Distinct Mechanism Evolved for Mycobacterial RNA Polymerase and Topoisomerase I Protein-Protein Interaction. J Mol Biol, 429(19), 2931-2942.
4.Cao, N., Tan, K., Annamalai, T., Joachimiak, A., and Tse-Dinh, Y. C. (2018). Investigating mycobacterial topoisomerase I mechanism from the analysis of metal and DNA substrate interactions at the active site. Nucleic Acids Res. 46(14):7296-7308.
5.Cao, N., Tan, K., Zuo,X., Annamalai, T., Joachimiak, A., and Tse-Dinh, Y. C. (2020). Mechanistic insights from structure of Mycobacterium smegmatis topoisomerase I with ssDNA bound to both N- and C-terminal domains. Nucleic Acids Res 48(8): 4448-4462.