南京中医药大学陈　琳

陈琳（邮箱：chenlin210046@163.com），医学博士，教授，硕士生导师，江苏省生理科学学会青年工作委员会委员。

长期从事生理学、神经生物学教学与科研工作。主讲《生理学》《高级神经生物学》等本科及研究生核心课程。近年来，主持及参与教改课题4项，参编“十四五”“十五五”国家级规划教材《生理学》《解剖生理学》等多部教材。曾获全国高等中医药院校优秀青年、全国高校青年教师教学竞赛及微课比赛奖项、南京中医药大学杏林优秀教学奖、五四青年奖章等荣誉。

科研方向聚焦中药有效成分体内直接作用靶点鉴定及分子机制研究，先后主持国家自然科学基金、江苏省自然科学基金、江苏省中医药科技发展计划、江苏省高校自然科学研究计划等多项课题。目前担任Phytother Res、J Ethnopharmacol、J Agric Food Chem、Eur J Pharmacol、Sci Rep等国际知名期刊审稿专家。

代表性研究论文：

[1] Zhang H, Chen F, Xu S, Zhang W, Li R, Yao Q, Zhao Y, Zhu Z*, Chen L*. Protective Effect of 20(S)-Protopanaxadiol on D-Gal-Induced Cognitively Impaired Mice Based on Its Target Protein Brain-type Creatine Kinase. J Agric Food Chem. 2023 Feb 8. doi: 10.1021/acs.jafc.2c07889. Epub ahead of print. PMID: 36752334.

[2] Chen L#, Li R#, Chen F#, Zhang H, Zhu Z, Xu S, Cheng Y, Zhao Y. A possible mechanism to the antidepressant-like effects of 20 (S)-protopanaxadiol based on its target protein 14-3-3 ζ. J Ginseng Res. 2022 Sep;46(5):666-674. doi: 10.1016/j.jgr.2021.12.004. Epub 2021 Dec 17. PMID: 36090685; PMCID: PMC9459030.

[3] Zhu Z, Li R, Qin W, Zhang H, Cheng Y, Chen F, Chen C, Chen L*, Zhao Y*. Target engagement of ginsenosides in mild cognitive impairment using mass spectrometry-based drug affinity responsive target stability. J Ginseng Res. 2022 Nov;46(6):750-758. doi: 10.1016/j.jgr.2021.12.003. Epub 2021 Dec 17. PMID: 36312734; PMCID: PMC9597435.

[4] Chen F, Li C, Cao H, Zhang H, Lu C, Li R, Zhu Z, Chen L*, Zhao Y*. Identification of Adenylate Kinase 5 as a Protein Target of Ginsenosides in Brain Tissues Using Mass Spectrometry-Based Drug Affinity Responsive Target Stability (DARTS) and Cellular Thermal Shift Assay (CETSA) Techniques. J Agric Food Chem. 2022 Mar 2;70(8):2741-2751. doi: 10.1021/acs.jafc.1c07819. Epub 2022 Feb 19. PMID: 35184563.

[5] Chen F#, Chen L#, Liang W, Zhang Z, Li J, Zheng W, Zhu Z, Zhu J, Zhao Y*. Identification and confirmation of 14-3-3 ζ as a novel target of ginsenosides in brain tissues. J Ginseng Res. 2021 Jul;45(4):465-472. doi: 10.1016/j.jgr.2020.12.007. Epub 2020 Dec 29. PMID: 34295206; PMCID: PMC8282492.