人才培养

王福顺

王福顺,教授,博士生导师,第四批江苏省特聘教授,南京中医药大学心理学院情绪心理学研究所所长。美国罗彻斯特大学客座教授(University of Rochester)。Plos One学术编委,Frontier in Psychology、International Journal of Neurology编委,Neural Plasticity客座主编,中华行为医学与脑科学杂志编委。中国老年医学常务理事,中国神经科学、中国心理卫生协会理事,世界神经科学、世界情绪研究协会、世界心脏协会会员。

研究方向及研究领域

于2013年12月从美国罗彻斯特大学回国,成立情绪心理学研究所,从事神经心理学、中西医结合相关研究。

主持科研项目

1.江苏省特聘教授启动基金,脑损伤导致癫痫的分子机制探讨,2014/01/01-2017/12/31, 100 万,在研,主持

2.江苏省自然基金,BK20151565,青礞石等中药物抗癫痫作用的分子机制研究探讨, 20万,在研,主持

3.江苏省中医药管理局课题重点项目,ZD201501,青礞石等抗癫痫药物对星形胶质细胞的作用机制研究 20 万,在研,主持

4.江苏省“六大人才高峰”基金, 2015YY006,青礞石等抗癫痫中药的机理研究,10 万,在研,主持

5.海外及港澳学者合作研究基金,星形胶质细胞通过调控神经元NKCC1表达介导脑损伤后早期癫痫发生的机制研究,81628007,2017/01/01-2018/12/31,18万,主持

研究成果( 获奖情况、发表论文)

论文

1. Fushun Wang*, Xiaosheng He, Shanshan Yu, Wei Wang, Simeng Gu., Maiken Nedergaard, Jason Huang.NKCC1 up-regulation contributes to early post-traumatic seizures. Brain Structure and function. in revision.

2. Fushun Wang*, Yuan Tifei, Pereira A Jr., Verkhrastsky A., Huang JH. Glial celss and synaptic plasticity. Neural Plasticity, 2016:5042902

3. Benraiss A., Wang S., Herrlinger S., Li X., CHandler-Militello D., Mauceri J., Burm HB., Toner M., Osipovitch M., Jim Xu Q., Ding F., Fushun Wang., Kang N., Kang J., Curtin PC., Brunner D., Windrem MS., Munoz-Sanjuan I., Nedergaard M., Goldman SA. Human glia can both induce and rescue aspects of disese phenotype in Huntington disease.Nature Communication, 2016, 7(7):11758.

4. SimengGu, Wei Wang,Fushun Wang*, Jason H Huang. Neuromodulator and emotion biomarker for stress induced mental disorders.Neural Plasticity, 2016 : 2609128.

5. Xue W., Wang W., Gong T., Zhang H., Tao W., Xue L., Sun Y., Fushun Wang, Chen G. PKA-CREB-BDNF signaling regulated long lasting antidepressant activities of Yueju but not ketamine. Scientific Report. 2016, 6: 26331.

6. SimengGu, Wei Wang,Yang Li, Fushun Wang*, Jason H Huang. Astrocytic modulation of potassium under seizures.Epileptic Research, 2016  in press.

7. Shanshan Lu, Fushun Wang*, Jason H Huang. Astrocytic changes under seizure. Internaltional Journal of Brain Disease and Therapy, 2016, 2(1): 1-5

8. SimengGu, Fushun Wang*, Tifei Yuan, BenyuGuo, Jason H Huang. Differential of primary emotions through neuromodulators: Review of Literature. International Journal of Neurology, 2015.1(2): 43-50

9. Fushun Wang*., Smith NA., Xu Q., Goldman N., Peng W., Takano T., Nedergaard M. Photolysis of caged Ca2+, but not receptor-mediated Ca2+ signaling triggers astrocytic glutamate release, Journal of Neuroscience, 2013 ,33(44):17404-12

10. Fushun Wang*.,Smith NA, Xu Q, Fujita T, Baba A, Matsuda T, Takano T, Bekar L, Nedergaard M*.Astrocytes modulate neural network activity byCa²+-dependent uptake of extracellular K+ ,ScienceSignaling,2012 ,5(218): 26

11. Fushun Wang, Xu Q, Wang W, Takano T, Nedergaard M*.Bergmann glia modulate cerebellar Purkinje cell bistability via Ca2+-dependent K+uptake, ProcNatlAcadSci U S A,2012 ,109(20):7911-6

12. Fushun Wang, Xiao C, Ye JH*. Taurine activates excitatory non-synaptic glycine receptors on dopamine neurones in ventral tegmental area of young rats,J Physiol, 2005,565(2):503-16

13. Takano T, He W, Han X, Fushun Wang, Xu Q, Wang X, Oberheim Bush NA, Cruz N, Dienel GA, Nedergaard M.Rapid manifestation of reactive astrogliosis in acute hippocampal brain slices.Glia.2014 Jan; 62(1):78-95 doi: 10.1002/glia.22588.

14. Alexander Stanley Thrane, Vinita RangrooThrane, Fushun Wang, Maria Cotrina, Nathan Anthony Smith, Michael Chen, Qiwu Xu, Ning Kang, Takumi Fujita, ErlendNagelhus, and MaikenNedergaard. Ammonia short-circuits astroglial potassium buffering resulting in cortical disinhibition and seizures. Nature Medicine, 013 Dec. 19(12):1643-8. doi: 10.1038/nm.3400.

15. Ding F, O'Donnell J, Thrane AS, Zeppenfeld D, Kang H, Xie L, Wang Fushun, Nedergaard M.alpha-Adrenergic receptors mediate coordinated Ca2+ signaling of cortical astrocytes in awake, behaving mice.Cell Calcium. 2013 Sep 24. doi:pii: S0143-4160(13)00128-0. 10.1016/j.ceca.2013.09.001.

16. Benraiss A., Toner M., Xu Q., Bruel-jungerman E., Rogers EH.,Wang Fushun, Economides A., Davidson B., Kageyama R., Nedergaard M., Goldman S. Sustained Mobilization of Endogenous Neural Progenitors Delays Disease Progression in a Transgenic Model of Huntington’s Disease. CellStem Cell. 2012 Jun 6; 12(6):787-799. doi: 10.1016/j.stem.2013.04.014.

17. Thrane A., Takano T., Rangroo V., Wang Fushun, Peng W., Ottersen OP., Nedergaard M. Nagelhus EA.. In vivo NADH fluorescence imaging indicates effect of aquaporin-4 deletion on oxygen microdistribution in cortical spreading depression. Journal of Cerebral Bloodflow and Metabolism, 2013 April 24. doi: 10.1038/jcbfm.2013.63.)

18. Han X, Chen M, Wang Fushun, Windrem M, Wang S, Shanz S, Xu Q, Oberheim NA, Bekar L, Betstadt S, Silva AJ, Takano T, Goldman SA, Nedergaard M. Forebrain engraftment by human glial progenitor cells enhances synaptic plasticity and learning in adult mice.CellStem Cell 2013 Mar 7;12(3):342-53.doi: 10.1016/j.stem.2012.12.015

19. Thrane AS, Rappold PM, Fujita T, Torres A, Bekar LK, Takano T, Peng W, Wang Fushun, RangrooThrane V, Enger R, Haj-Yasein NN, Skare Ø, Holen T, Klungland A, Ottersen OP, Nedergaard M, Nagelhus EA.Critical role of aquaporin-4 (AQP4) in astrocytic Ca2+ signaling events elicited by cerebral edema.ProcNatlAcadSci U S A. 2011 Jan 11;108(2):846-51. doi: 10.1073/pnas.1015217108

20. Torres A, Wang Fushun, Xu Q, Fujita T, Dobrowolski R, Willecke K, Takano TT.,Ndergaard M. Extracellular Ca²+ acts as a mediator of communication from neurons to glia.Science Signaling 2012 Jan 24:5(208). doi:10.1126/scisignal.200

21. Goldman N, Chen M, Fujita T, Xu Q, Peng W, Liu W, Jensen TK, Pei Y, Wang Fushun, Han X, Chen JF, Schnermann J, Takano T, Bekar L, Tieu K, Nedergaard M. Adenosine A1 receptors mediate local anti-nociceptive effects of acupunctureNatureNeuroscience. 2010 Jul;13(7):883-8. doi: 10.1038/nn.2562.

22. Oberheim NA, Takano T, Han X, He W, Lin JH, Wang Fushun, Xu Q, Wyatt JD, Pilcher W, Ojemann JG, Ransom BR, Goldman SA, Nedergaard M. Uniquely hominid features of adult human astrocytesJ Neurosci. 2009 Mar 11;29(10):3276-87.  doi: 10.1523/J of Neuroscience.4707-08.2009

23. Lai M, Fushun Wang, Rohan JG, Maeno-Hikichi Y, Chen Y, Zhou Y, Gao G, Sather WA, Zhang JF.A tctex1-Ca2+ channel complex for selective surface expression of Ca2+ channels in neurons.Nature Neuroscience. 2005 Apr;8(4):435-42.

24. Li D, Fushun Wang, Lai M, Chen Y, Zhang JF. A protein phosphatase 2calpha-Ca2+ channel complex for dephosphorylation of neuronal Ca2+ channels phosphorylated by protein kinase C.J Neurosci. 2005 Feb 23;25(8):1914-23

25. Ye JH, Fushun Wang, Krnjevic K, Wang W, Xiong ZG, Zhang J. Presynaptic glycine receptors on GABAergic terminals facilitate discharge of dopaminergic neurons in ventral tegmental area.J Neuroscience. 2004 Oct 13;24(41):8961-74

26. Jiang Z, Krnjević K, Fushun Wang, Ye JH. Taurine activates strychnine-sensitive glycine receptors in neurons freshly isolated from nucleus accumbens of young rats.J Neurophysiol. 2004 Jan; 91(1):248-57.

27. Cho KJ, Trzaska KA, Greco SJ, McArdle J, Fushun Wang, Ye JH, Rameshwar P . Neurons derived from human mesenchymal stem cells show synaptic transmission and can be induced to produce the neurotransmitter substance P by interleukin-1 alpha.Stem Cells. 2005 Mar;23(3):383-91.

28. Zhu L, Jiang ZL, Krnjević K, Fushun Wang, Ye JH.Genistein directly blocks glycine receptors of rat neurons freshly isolated from the ventral tegmental area.Neuropharmacology. 2003 Aug;45(2):270-8

专著

1. 李昌英王福顺主编《医学心理学》,中国医药科技出版社,1997

2. 主编:罗向阳梁立阳黄怀编委:王福顺《实用小儿神经病学》,世界图书出版社, 2011

3. 主编 :王福顺吴海英主编《医学心理学》,江苏人民出版社, 2014

4. 主编:王福顺付文清主编《中医情绪心理学》,中国中医药出版社,2015

5. 主编:李洋王福顺主编《心身疾病学》,中国医药出版社,2016

6. 主编:王福顺主编《情绪心理学》,中国人民卫生出版社,2017,十三五规划教材。

授权发明专利

1. 王福顺,一种用于治疗癫痫的药物制剂,2015年10月,中国,201510504819.61

2. 王福顺,一种治疗老年痴呆的药物制剂,2015年12月,中国,201510507612.4